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3.2 Attention deficit hyperactivity disorder

CNS stimulants and drugs used for ADHD

NICE NG87 Attention deficit hyperactivity disorder: diagnosis and management

CNS stimulants and drugs used for ADHD Preparations Comments
Atomoxetine hydrochloride 10mg,18mg, 25mg, 40mg, 60mg, 80mg capsules Consider shared care once patient is stabilised.
Atomoxetine is significantly more expensive than other treatment options for ADHD.
Dexamfetamine sulphate 5mg tablets CD.
Consider shared care once patient is stabilised.
Guanfacine hydrochloride 1mg, 2mg, 3mg, 4mg MR tablets For specialist initiation in line with HPFT prescribing guidelines on pharmacological management of ADHD. Prescribing responsibility to remain with HPFT  
Lisdexamfetamine 20mg, 30mg, 40mg, 50mg, 60mg, 70mg capsules CD. NICE CG 87 ADHD: diagnosis and management
Methylphenidate hydrochloride Immediate release
5mg, 10mg, 20mg tablets
Modified release
Delmosart® XL: 18mg, 27mg and 36mg MR tablets
Equasym XL®: 10mg, 20mg and 30mg MR capsules
Medikinet XL®: 5mg, 10mg, 20mg, 30mg, 40mg MR capsules
Consider shared care once patient is stabilised.
Different versions of modified release preparations may not have the same clinical effect. To avoid confusion between these different formulations prescribe by brand name.
  % dose immediate release % dose modified release
Delmosart® XL 25 75
Equasym XL® 30 70
Medikinet XL® 50 50


 Alpha2-adrenergic agonist  Preparations Comments
Clonidine 25 microgram tablets

Off label use in children with ADHD and sleep disturbance, rages or tics on the advice of tertiary ADHD service (NICE CG87)


Continue to 3.3 Bipolar disorder and mania


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