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Selective serotonin re-uptake inhibitors (SSRIs)

Selective serotonin re-uptake inhibitors (SSRIs) Preparations Comments
Citalopram hydrobromide (Tabs) 10mg, 20mg, 40mg tablets SSRI with lowest propensity for drug interactions. Suitable choice in renal impairment.
Citalopram and escitalopram: QT interval prolongation—new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings : MHRA Dec 11
Be aware of bioequivalence to drops. See Citalopram tablets to drops conversion
Citalopram hydrochloride (Drops) 40mg/ml oral drops
Escitalopram 5mg, 10mg and 20mg tablets
20mg/ml oral drops
Not approved. Named patient request ONLY
Fluoxetine hydrochloride 20mg, 30mg capsules
20mg/5ml oral liquid
60mg capsules NOT approved. For 60mg dose prescribe 3 x 20mg capsules or 2 x 30mg capsules – this is more cost-effective than 1x 60mg capsule.
Fluvoxamine maleate† 50mg tablets Less cost-effective choice than other SSRIs. Use only when other SSRIs are not suitable.
Paroxetine† hydrochloride 20mg and 30mg tablets Less preferred choice. SSRI with greatest risk of withdrawal reactions.
Sertraline hydrochloride 50mg and 100mg tablets Suitable choice for those with cardiovascular disease (recent MI or unstable angina) or renal impairment.

† - denotes a less preferred choice of medicine.


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