Tricyclic antidepressant drugs
| Tricyclic anti -depressant drugs | Preparations | Comments |
| Increased risk of cardiotoxicity with tricyclic antidepressants and more dangerous in overdose than SSRIs. See HPFT Guidelines on Prescribing TCAs. | ||
| Amitriptyline hydrochloride | 10mg, 25mg and 50mg tablets 25mg/5ml and 50mg/5ml oral solution |
|
| Clomipramine hydrochloride | 10mg, 25mg and 50mg capsules 75mg modified release tablets |
MR preparation considered to be less suitable for prescribing by BNF. MR preparation more expensive. |
| Imipramine hydrochloride | 10mg and 25mg tablets 25mg/5ml oral solution |
|
| Lofepramine hydrochloride | 70mg tablets 70mg/5ml oral suspension |
Lower incidence of side-effects and less dangerous in overdose. |
| Nortriptyline | 10mg and 25mg tablets | |
| Trazodone hydrochloride | 50mg and 100mg capsules 150mg tablets 50mg/5ml sugar free oral solution |
Oral liquid significantly more expensive than tabs/caps. Restricted to those unable to swallow solid dose forms. |
Back to 4.3.2 Monoamine-oxidase inhibitors (MAOI's)
Back to 4.3.3 Selective serotonin re-uptake inhibitors (SSRI's)
Continue to 4.3.4 Other antidepressant drugs